Spruce Biosciences Inc (SPRB)

$69.90

up-down-arrow $-0.41 (-0.58%)

As on 20-Apr-2026 16:29EDT

Market cap

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$96 Mln

Revenue (TTM)

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$1 Mln

P/E Ratio

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--

P/B Ratio

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2.2

Div. Yield

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0 %

Spruce Biosciences Inc (SPRB) Share Price

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Stock Range

Today’s Range

Low: 67.67 High: 70.68

52 Week Range

Low: 0.06 High: 104.46

Liquidityliquidity Low

Low Moderate High

Fundamentals

  • Net Profit (TTM)Net Profit (TTM) information

    $0 Mln

  • ROEROE information

    -1.1 %

  • ROCEROCE information

    -- %

  • Industry P/EIndustry P/E information

    --

  • EV/EBITDAEV/EBITDA information

    -0.2

  • Debt to EquityDebt to Equity information

    0

  • Book ValueBook Value information

    $42.5

  • EPSEPS information

    $-39

  • Face valueFace value information

    --

  • Shares outstandingShares outstanding information

    1,372,278

6 Years Aggregate

CFO

$-159.54 Mln

EBITDA

$-191.71 Mln

Net Profit

$-188.81 Mln

Performance

Company
YTD
1 Month
3 Months
1 Year
3 Years
5 Years
10 Years
Spruce Biosciences Inc (SPRB)
-19.8 18.4 -4.9 58,783.7 220.7 35.0 --
BSE Sensex*
-6.4 6.4 -3.5 0.9 10.0 10.7 11.9
S&P Small-Cap 600#
-5.8 -5.3 -13.7 -6.3 5.3 3.0 5.5
As on 20-Apr-2026  |  *As on 21-Apr-2026  |  #As on 26-Oct-2023
Company
2025
2024
2023
2022
2021
Spruce Biosciences Inc (SPRB)
20,640.5 -85.4 167.0 -75.4 -81.7
S&P Small-Cap 600
4.0 7.0 13.9 -17.4 25.3
BSE Sensex
9.1 8.1 18.7 4.4 22.0

Essential Checks

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Is there a threat to the company's solvency?

Can creative accounting be detected through the financial numbers?

How did the company perform in the last one year?

Financials

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*All values are in ($ Mln)

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*All values are in ($ Mln)

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*All values are in ($ Mln)

Key Ratios

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5Y Avg -- 3Y Avg -- TTM --

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P/E Ratio

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--Min --Median --Max

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P/B Ratio

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--Min --Median --Max

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Earnings Yield (%)

--

Earnings Yield (%) = EBIT / Enterprise value

PEG Ratio

--

Price = Price / Earnings to growth ratio

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Peers

View Details
Company
Price ($) Market Cap ($ Mln) Revenue (TTM) Net Profit (TTM) OPM (%) ROE (%) P/E P/B
Spruce Biosciences Inc (SPRB)
69.9 96.5 0.0 -39.0 -5,069.7 -109.2 -- 2.2
69.3 9,733.6 1,091.0 202.3 31.6 31.3 43.4 17.1
66.1 8,216.2 88.0 -785.0 -808.1 197.5 -- 60.3
43.6 11,658.3 2,320.1 782.6 39.0 35.5 16.1 5.3
91.1 11,852.6 982.0 -416.3 -42.1 348.4 -- 55.7
69.6 8,209.1 1,396.6 316.9 59.8 153.6 27.1 161.7
527.1 12,204.5 958.4 -288.3 -27.8 -42.5 -- 20.3
528.4 14,867.3 2,530.2 451.1 21.3 70.2 34 32.4
108.2 8,460.0 0.0 -425.4 -- -36.7 -- 6.8
342.6 9,538.9 0.0 -303.3 -- -45.8 -- 10.9

Shareholding Pattern

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About Spruce Biosciences Inc (SPRB)

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase,...  which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.  Read more

  • Executive Chairman

    Mr. Michael G. Grey

  • Executive Chairman

    Mr. Michael G. Grey

  • Headquarters

    South San Francisco, CA

  • Website

    https://sprucebio.com

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FAQs for Spruce Biosciences Inc (SPRB)

The share price of Spruce Biosciences Inc (SPRB) is $69.90 (NASDAQ) as of 20-Apr-2026 16:29 EDT. Spruce Biosciences Inc (SPRB) has given a return of 220.65% in the last 3 years.

Since, TTM earnings of Spruce Biosciences Inc (SPRB) is negative, P/E ratio is not available.


PE & PB ratio at the end of financial year.


Year P/E Ratio P/B Ratio
2025
-2.24
2.05
2024
-0.01
0.01
2023
-0.06
0.04
2022
--
--
2021
--
--

The 52-week high and low of Spruce Biosciences Inc (SPRB) are Rs 104.46 and Rs 0.06 as of 21-Apr-2026.

Spruce Biosciences Inc (SPRB) has a market capitalisation of $ 96 Mln as on 17-Apr-2026. As per SEBI classification, it is a Small Cap company.

Before investing in Spruce Biosciences Inc (SPRB), assess your goals, risk tolerance, and if the company aligns with your long-term plan. Carefully review its business model, financials, and valuation. Avoid making decisions based on tips or short-term trends.

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