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Karyopharm Therapeutics (KPTI) Key Ratios

Stock Card factsheet share-fund-plan-icon

$0.61

up-down-arrow $-0.04 (-5.43%)

As on 08-Oct-2026 10:37EDT

Market cap

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$18 Mln

Revenue (TTM)

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$147 Mln

P/E Ratio

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--

P/B Ratio

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12

Div. Yield

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0 %

Key Ratios and Highlights

Growth Score (%) Quarterly Annual (TTM)
Particulars QoQ YoY 1-Year 3-Years 5-Years
Revenue -4.66 -11.86 6.81 0.14 7.47
EBIT -447.66 -107.35 -123.46 -20.35 0.81
Net Profit -199.32 -79.92 -81.88 -25.55 -1.67
EPS -155.64 46.41 13.37 8.84 10.20
Book Value -- -- -- -- --
Key Ratios (%) Average Annual (TTM)
Particulars3-Years5-YearsTTMDec-25Dec-24
EBIT-Margin info -70.35-69.35-120.04-102.79-26.81
Net Margin info ---81.36-153.28----
Return on equity info 105.51302.35--81.8647.43
Return on Capital info 106.9620.77--771.62-309.92
Return on Assets info -76.42-63.85-99.96-143.71-37.75
Debt to Equity (x) info -----0.63-0.80-1.05

Profitability

View Detailed Peer Comparison

ROCE

--

--

Earning before interest and taxes / (Average net worth + Average total Debt) * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
771.62
-309.92
-140.83
-125.54
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
ROE

--

--

Profit after tax / Average Net worth * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
81.86
47.43
187.23
343.18
Peer Median
-39.75
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
ROA

-99.96

Lower than Peers by 68.77

Profit after tax / Average Total assets * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-99.96
-143.71
-37.75
-47.81
-49.83
Peer Median
-31.19
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EBIT Margin

-120.04

Lower than Peers by 43.51

Operating profit (EBIT) / Net Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-120.04
-102.79
-26.81
-81.46
-89.08
Peer Median
-76.53
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Net Margin

-153.28

Lower than Peers by 67.71

Net profit / Total Income (Net sales plus other income) * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-153.28
-134.21
-52.62
-97.99
-103.73
Peer Median
-85.56
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Cash Profit Margin

0.00

Lower than Peers by 0.00

(Net profit + Depreciation) / Gross Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
0.00
--
--
--
--
Peer Median
0.00
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Growth

View Detailed Peer Comparison

Revenue Growth

6.81

Lower than Peers by 47.81

Year on year growth in net sales

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
6.81
0.01
-0.01
-0.07
-0.25
Peer Median
54.63
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EBIT Growth

-123.46

Lower than Peers by 122.08

Year on year growth in operating profit (EBIT)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-123.46
-285.56
67.26
14.99
-43.11
Peer Median
-1.39
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Net Profit Growth

-81.88

Lower than Peers by 75.08

Year on year growth in profit after tax

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-81.88
-156.52
46.60
13.43
-33.20
Peer Median
-6.80
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EPS Growth

13.37

Lower than Peers by 0.76

Year on year growth in earnings per share

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
13.37
-0.18
0.51
0.32
-0.29
Peer Median
14.14
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Book Value Growth

58.84

Higher than Peers by 68.33

Year on year growth in book value per share

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
58.84
--
--
--
--
Peer Median
-9.50
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Solvency

View Detailed Peer Comparison

Debt to Equity

-0.63

--

Total debt / Net worth

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-0.63
-0.80
-1.05
-1.30
-10.75
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Short term debt to equity ratio

0.00

--

(Short term borrowings / Net worth)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
0.00
-0.08
-0.13
-0.02
-0.17
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Current Ratio

0.79

Lower than Peers by 5.04

Current Assets / Current Liabilities and Provisions

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
0.79
1.12
1.70
3.37
5.31
Peer Median
5.84
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Quick Ratio

0.76

Lower than Peers by 4.94

(Current Assets - Inventory) / Current Liabilities and Provisions

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
0.76
1.08
1.64
3.32
5.25
Peer Median
5.70
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Interest Coverage

-3.56

Lower than Peers by 1.41

Earning before interest and taxes (EBIT) / Interest Expenses

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-3.56
-3.27
-1.04
-4.99
-5.60
Peer Median
-2.15
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Operating Efficiency

View Detailed Peer Comparison

Debtors to sales

20.37

Higher than Peers by 1.32

Debtors outstanding / Net Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
20.37
17.92
21.18
18.46
29.98
Peer Median
19.05
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Asset Turnover

0.65

Higher than Peers by 0.59

Sales / Average Total Assets

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
0.65
1.07
0.72
0.49
0.47
Peer Median
0.07
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Receivable days

--

--

Average Debtors / Sales * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
71.20
72.59
92.60
80.90
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Inventory Days

--

--

Average Inventory / Sales * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
269.44
236.59
268.54
291.82
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Payable days

--

--

Average Creditors / Cost of goods sold * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
279.66
250.21
217.88
153.30
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Cash Conversion Cycle

--

--

Receivable Days + Inventory Days - Payable Days

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
60.97
58.97
143.27
219.42
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Valuation

View Detailed Peer Comparison

Price / Earnings

--

--

Current share price divided by earning per share in the last twelve months

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
-0.68
-0.07
-0.05
-0.12
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Price / Book Value

12.05

Higher than Peers by 7.57

Current share price divided by book value per share in the latest financial year

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
12.05
-0.46
-0.03
-0.05
-1.22
Peer Median
4.48
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Dividend Yield

--

--

Dividend per share in the past twelve months divided by current share price

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
--
--
--
--
--
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EV/EBITDA

-1.85

--

Enterprise Value (Current Market Capitalisation + Total Debt - Cash & Equivalents) / Earnings before interest, taxes, depreciation and taxes (EBITDA)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
-1.85
-2.03
-2.37
0.07
0.56
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Market Cap

18

Lower than Peers by 123

Current Share price multiplied by latest total number of shares outstanding

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Karyopharm Therapeutics (KPTI)
18
--
--
--
--
Peer Median
142
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
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