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Ionis Pharmaceuticals (IONS) Key Ratios

Stock Card factsheet share-fund-plan-icon

$58.64

up-down-arrow $0.51 (0.88%)

As on 04-Sep-2026 13:36EDT

Market cap

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$10,146 Mln

Revenue (TTM)

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$874 Mln

P/E Ratio

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--

P/B Ratio

info icon

23.6

Div. Yield

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0 %

Key Ratios and Highlights

Growth Score (%) Quarterly Annual (TTM)
Particulars QoQ YoY 1-Year 3-Years 5-Years
Revenue 8.88 -40.73 -7.45 11.48 4.91
EBIT -44.42 -175.12 -165.20 -137.60 -183.30
Net Profit -23.90 -192.79 -110.57 -44.34 -0.59
EPS -23.50 -202.28 -87.06 -26.32 1.77
Book Value -- -- -18.92 -9.21 -12.90
Key Ratios (%) Average Annual (TTM)
Particulars3-Years5-YearsTTMDec-25Dec-24
EBIT-Margin info -39.54-32.84-57.44-32.52-53.28
Net Margin info ---19.78-64.64----
Return on equity info -80.06-56.76-121.61-70.72-93.10
Return on Capital info -19.30-14.63---14.92-23.61
Return on Assets info -13.36-10.34-15.70-11.67-15.15
Debt to Equity (x) info ----3.075.352.41

Profitability

View Detailed Peer Comparison

ROCE

--

--

Earning before interest and taxes / (Average net worth + Average total Debt) * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
-14.92
-23.61
-19.37
-13.70
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
ROE

-121.61

Lower than Peers by 81.21

Profit after tax / Average Net worth * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-121.61
-70.72
-93.10
-76.34
-40.11
Peer Median
-40.40
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
ROA

-15.70

Higher than Peers by 15.27

Profit after tax / Average Total assets * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-15.70
-11.67
-15.15
-13.26
-10.48
Peer Median
-30.98
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EBIT Margin

-57.44

Higher than Peers by 26.18

Operating profit (EBIT) / Net Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-57.44
-32.52
-53.28
-32.80
-42.54
Peer Median
-83.62
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Net Margin

-64.64

Higher than Peers by 28.03

Net profit / Total Income (Net sales plus other income) * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-64.64
-40.36
-64.37
-46.50
-36.07
Peer Median
-92.67
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Cash Profit Margin

0.00

Higher than Peers by 0.00

(Net profit + Depreciation) / Gross Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
0.00
--
--
--
--
Peer Median
0.00
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Growth

View Detailed Peer Comparison

Revenue Growth

-7.45

Lower than Peers by 61.40

Year on year growth in net sales

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-7.45
0.34
-0.10
0.34
-0.28
Peer Median
53.95
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EBIT Growth

-165.20

Lower than Peers by 164.40

Year on year growth in operating profit (EBIT)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-165.20
18.29
-45.42
-3.40
-909.63
Peer Median
-0.80
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Net Profit Growth

-110.57

Lower than Peers by 103.27

Year on year growth in profit after tax

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-110.57
16.06
-23.92
-35.80
-843.18
Peer Median
-7.30
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EPS Growth

-87.06

Lower than Peers by 101.71

Year on year growth in earnings per share

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-87.06
0.18
-0.14
-0.33
-9.63
Peer Median
14.65
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Book Value Growth

-23.27

Lower than Peers by 13.10

Year on year growth in book value per share

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-23.27
--
--
--
--
Peer Median
-10.18
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Solvency

View Detailed Peer Comparison

Debt to Equity

3.07

--

Total debt / Net worth

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
3.07
5.35
2.41
3.76
2.39
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Short term debt to equity ratio

0.55

--

(Short term borrowings / Net worth)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
0.55
0.93
0.02
0.14
0.01
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Current Ratio

7.88

Higher than Peers by 2.07

Current Assets / Current Liabilities and Provisions

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
7.88
3.83
8.47
5.90
7.07
Peer Median
5.81
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Quick Ratio

7.72

Higher than Peers by 2.03

(Current Assets - Inventory) / Current Liabilities and Provisions

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
7.72
3.81
8.43
5.88
7.00
Peer Median
5.70
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Interest Coverage

-5.28

Lower than Peers by 3.19

Earning before interest and taxes (EBIT) / Interest Expenses

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
-5.28
-3.39
-4.15
-3.17
-30.76
Peer Median
-2.09
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Operating Efficiency

View Detailed Peer Comparison

Debtors to sales

6.73

Lower than Peers by 12.41

Debtors outstanding / Net Sales * 100

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
6.73
6.99
13.07
12.41
4.35
Peer Median
19.14
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Asset Turnover

0.24

Higher than Peers by 0.18

Sales / Average Total Assets

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
0.24
0.29
0.24
0.29
0.23
Peer Median
0.06
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Receivable days

--

--

Average Debtors / Sales * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
30.60
49.20
28.59
27.22
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Inventory Days

--

--

Average Inventory / Sales * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
257.50
324.91
589.37
605.98
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Payable days

--

--

Average Creditors / Cost of goods sold * 365

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
810.92
1,123.45
878.79
385.86
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Cash Conversion Cycle

--

--

Receivable Days + Inventory Days - Payable Days

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
-522.82
-749.33
-260.83
247.34
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.

Valuation

View Detailed Peer Comparison

Price / Earnings

--

--

Current share price divided by earning per share in the last twelve months

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
-33.64
-12.17
-20.10
-19.88
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Price / Book Value

23.59

Higher than Peers by 18.41

Current share price divided by book value per share in the latest financial year

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
23.59
26.20
9.39
19.04
9.36
Peer Median
5.18
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Dividend Yield

--

--

Dividend per share in the past twelve months divided by current share price

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
--
--
--
--
--
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
EV/EBITDA

135.77

--

Enterprise Value (Current Market Capitalisation + Total Debt - Cash & Equivalents) / Earnings before interest, taxes, depreciation and taxes (EBITDA)

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
135.77
-44.47
-13.13
-27.49
-20.79
Peer Median
--
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
Market Cap

10,146

Higher than Peers by 10,000

Current Share price multiplied by latest total number of shares outstanding

Company Name
TTM
Dec-25
Dec-24
Dec-23
Dec-22
Ionis Pharmaceuticals (IONS)
10,146
--
--
--
--
Peer Median
146
--
--
--
--
*TTM (Trailing Twelve Months) data based on income statement of last 4 quarters and interim half yearly balance sheet.
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